Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs, Treatment and Prophylaxis
Abstract
The work reported herein was directed at the preparation of improved antileishmanial and antitrypanosomal drugs. During the contact period (forty six months), 46 candidate drugs were submitted for biological testing. This program was divided into five phases of work: (1) Analogs of WR 6026 (eleven); (2) Potential metabolites and analogs of a known metabolite WR 6026 (seven); (3) Bis-amidoxime and bis-amidines (four); (4) Dimethylaminomethyl ethylenes (similar to Burroughs Welcome 353 C) (seventeen); and (5) Amidoximinio ethylenes (seven). Twenty eight of the target compounds prepared were directed against Trypanosoma cruzi infections, while the remaining eighteen compounds were targeted against Leishmaniasis. Keywords: Antileishmanials, Metabolites of 8-(6- diethylaminohexylamino)-6-methoxy-4-methylquinoline, WR 6026, RA 1, Organic compounds, Drugs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1989
- Accession Number
- ADB145101
Entities
People
- A. B. Ash
- A. Markovac
- C. L. Stevens
- D. J. Dagli