Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies

Abstract

SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pinchinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates will be screened for antiviral activity both in vitro and in animal model systems.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1989
Accession Number
ADB146426

Entities

People

  • Bill B. Barnett
  • Marcia I. Dawson
  • Robert W. Sidwell

Organizations

  • SRI International

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Bacterial Infections And Mycoses
  • Biomedical Research
  • Diseases And Disorders
  • Governments
  • Infection
  • Universities
  • Wound Infections

Readers

  • Immunology
  • Virology (or Medical Virology).