Testing Compounds for Efficacy against Schistosomiasis.
Abstract
During this four year funding period, attempts were made to determine the efficacy of the compound Niclosamide as a potential Topical Antipenetrant (TAP) against cercariae (ineffective larval) of Schistosoma mansoni, S. haemotobium, and S.japonicum in monkey, hamster and mouse animal test models; to assess the potential for TAP to interact with new insect repellent when applied simultaneously to skin; determine the oral prophylactic activity of 28 candidate compounds against S. mansoni, S. haematobium and S. japonicum in monkey, hamster and mouse test models; to determine if the marmoset monkey can be employed as a model to study schistosome cercarial penetration dynamics and to provide drug-resistant schistosome strains for drug-tests when warranted. Keywords: Schistosomiasis, S. mansoni, S. haematobium, S. japonicum, Niclosamide, Prophylactic, Antischistosomal drug, Cercariae, Antipenetrant, Repellant, Cebus apella, Brazil, Kenya, Hamster, Mouse, Monkey, Mesoricetus auratus, Mus musculus, Toxicity, Dermal Toxicity, RAI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 19, 1990
- Accession Number
- ADB147447
Entities
People
- John I. Bruce