Research in Drug Development against Viral Diseases of Military Importance (Biological Testing)

Abstract

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical compounds and natural products for antiviral efficacy in vitro using CPE-inhibition, plaque-reduction, and MTT assays, (b) primary testing of compounds for antiviral efficacy in vivo in animal model systems, and (c) secondary evaluation of the active candidate antiviral compounds. The target viruses for in vitro testing are Vaccinia Virus (VV), Adenovirus (AD2), Vesicular Stomatitis Virus (VSV), Punta Toro Virus (PT), Sandfly Fever Virus (SF), Yellow Fever Virus (YF), Venezuelan Equine Encephalomyelitis Virus (VE), Japanese Encephalitis Virus (JE), Pichinde Virus (PIC), and Hantaan VIrus (HTN). The current in vivo systems are Pichinde Virus infection of hamsters, Venezuelan Equine Encephalomyelitis Virus, Japanese Encephalitis Virus and Vaccinia Virus infections of mice.

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Document Details

Document Type
Technical Report
Publication Date
Dec 15, 1989
Accession Number
ADB148208

Entities

People

  • A. D. Brazier
  • E. A. Dulmadge
  • G. Arnett
  • J. J. Kirsi
  • L. J. Wilkoff
  • L. Westbrook
  • M. G. Hollingshead
  • W. M. Shannon

Organizations

  • Southern Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Diseases
  • Arbovirus Infections
  • Biological Products
  • Encephalitis
  • Flavivirus Infections
  • Infection
  • Mouth Diseases
  • Phlebotomus Fever
  • Poxviridae Infections
  • Rna Viruses
  • Test And Evaluation
  • Venezuelan Equine Encephalomyelitis
  • Venezuelan Equine Encephalomyelitis Virus
  • Virus Diseases
  • Viruses
  • Wound Infections
  • Yellow Fever

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).