Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies

Abstract

SRI International and Utah State University developed methodology to assess the effectiveness of antiviral drug monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates were screened for antiviral activity in vitro. Immunoconjugates were inactive because the monoclonal antibody did not internalize. Subsequent work using a polyclonal antibody produced an immunotoxin that had antiviral activity. Animal model systems were developed for in vivo evaluations.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADB148458

Entities

People

  • Bill B. Barnett
  • Marcia I. Dawson
  • Robert W. Sidwell

Organizations

  • SRI International

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Bacterial Infections And Mycoses
  • Biomedical Research
  • Diseases And Disorders
  • Governments
  • Infection
  • Test And Evaluation
  • Test Methods
  • Universities
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Virology (or Medical Virology).