Bridged Bicyclic Systems as Acetylcholinesterase Reactivators and Pretreatment Drugs.
Abstract
During the past year a large number substituted carbamates, thiocarbamates of various bridged aza bicyclic oximes and their methiodides and meth chlorides have been synthesized. Among these are: (i) O-(N-Substituted carbamoyl)-3-tropinone oxime methiodides and methchlorides, (ii) 0-(N-Substituted carbamoyl)-6-cyano trop-3-ene-2-one oxime methiodides, (iii) O-N-(2',3',4',6'-Tetra-0-acetyl-b-D-glucopyranosyl thiocarbamoyl)-3-tropinone oxime and its methiodide. Synthesis of 1,6-bis-N',N'-dimethyl-3'-oximino-0-carbamoyl tropanonium-N-y1 hexane diiodide and 2,5- bis-(N'N'-dimethyl-3'-oximino-0-carbamoyl tropanonium-N-yl)-toluene diiodide have been achieved. From phencyclidine a series 4-phenyl-4-0-(N-substituted carbamoyl)-4'-piperidone oxime-1'-yl-1-methyl piperidone methiodides have been synthesized. Syntheses of 0-N-substituted carbamoyl)-3-exo-dimethyl aminomethyl2-norbornone oximes and their methiodides have been accomplished.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 30, 1990
- Accession Number
- ADB150776
Entities
People
- Robert M. Moriarty
Organizations
- University of Illinois at Chicago