Crossover Comparison of the Pharmacokinetics of Atropine and Pralidoxime Chloride in Three Multichambered Autoinjector Systems and the Mark 1. Task 90-15

Abstract

Eight sheep were injected in a crossover study with four different auto injectors with at least a 1-week wash out between auto injectors. The pharmacokinetics of atropine and pralidoxime chloride was used to compare the different auto injectors against the standard Mark I. Results were normalized for dose since there was significant difference in the doses contained between the different auto injectors. When two of the auto injectors (MCA-A and MCA-B) were used, the atropine and 2-PAM were absorbed more rapidly than with the standard or the third auto injector (MCA). The maximum 2-PAM concentrations were also higher with these two. The MCA-A resulted in higher maximum atropine concentrations.

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Document Details

Document Type
Technical Report
Publication Date
Mar 30, 1991
Accession Number
ADB154015

Entities

People

  • Carl T. Olson
  • Garrett S. Dill
  • Robyn C. Kiser
  • Ronald G. Menton
  • Thomas H. Snider

Organizations

  • Battelle Memorial Institute

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  • Biomedical

DTIC Thesaurus Topics

  • Chemical Analysis
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  • Regression Analysis
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  • Veins

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  • Biology
  • Chemistry
  • Medicine

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