Characterization of Soman Toxicity in Atropine and Oxime (HI-6 and MMB- 4) Treated Rhesus Monkeys

Abstract

A study was instituted to characterize in rhesus monkeys the toxicity, based on lethality, morbidity, and pathology, of GD when exposure was followed by treatment with atropine and either of two test oximes, HI-6, and MMB-4. The 48 hour LD-50 was determined for untreated monkeys and monkeys treated with atropine/HI-6 and atropine MMB-4. HI-6 was significantly more effective than MMB-4 in treating GD intoxication. The times to death were significantly longer for animals treated with atropine/HI-6. Duration of tremors, convulsions, and prostration were determined to not be significantly related to either GD dose or treatment group.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 30, 1991
Accession Number
ADB154041

Entities

People

  • Carl T. Olson
  • M. C. Matthews
  • Robyn C. Kiser
  • Ronald C. Menton
  • Timothy L. Hayes

Organizations

  • Battelle Memorial Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Body Weight
  • Brain
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peripheral Nervous System
  • Skeletal Muscle
  • Statistical Analysis

Fields of Study

  • Biology
  • Medicine
  • Psychology

Readers

  • Neurotoxicology
  • Parasitology and Pharmacology of Malaria.
  • Toxicology/Environmental Toxicology