Systematic Mustard Gas Scavengers

Abstract

The synthesis methodology for preparing four types of novel nucleophilic scavengers for experimental treatment of HD intoxication is described. The four types include 3-alkoxyquinuclidines, 4-(dialkyl) aminopyridines, N-alkylpyridine-4-thiones, and imidazoline-2-thiones. A total of 4 compounds representing three of the classes were prepared, characterized, and submitted to WRAIR for biological evaluation. In addition, a convenient kinetic screen to rank target compounds in order of relative reactivity was established.

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Document Details

Document Type
Technical Report
Publication Date
Apr 17, 1991
Accession Number
ADB155800

Entities

People

  • R. Harris Iii
  • R. Sanderson

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Biomedical Research
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Contracts
  • Ethers
  • Materials
  • Medical Personnel
  • Monitoring
  • Mustard Agents
  • Physical Properties
  • Silica Gels
  • Sodium Hydroxide
  • Therapy

Fields of Study

  • Chemistry

Readers

  • Computational Modeling and Simulation
  • Organic Chemistry
  • Parasitology and Pharmacology of Malaria.