Synthesis of Potential Prophylactic Agents Against Cyanide Intoxication.
Abstract
The goal of the proposed research is to identify through synthesis and testing compounds that may provide prophylaxis against cyanide intoxication. A review of the literature for both antidotes and prophylactic agents against cyanide has enabled us to conclude that better prophylaxis cyanide might be achieved from one or all of the following approaches. (1) Through the administration of sulfur-rich compounds such as polysulfide analogues of cysteine and similar compounds such as thioalkanoic acids, alkylthiols, and aminothiols which will act like cysteine to provide sulfur for sulfurtransferase reactions. (2) The use of compounds containing carbonyl groups. These compounds would be analogues of pyruvate and a -ketoglutarate and would bind directly to cyanide forming relatively stable and nontoxic cyanohydrins. (3) Exploring other compounds that can bind cyanide directly; of particular interest are two compound classes: (a) N-alkoxy heterocyclic compounds that react with cyanide ion to form covalent products and (b) structurally similar N-arylthio compounds which react with cyanide ion to give arylthiocyanates.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 19, 1991
- Accession Number
- ADB157099
Entities
People
- James R. Piper
Organizations
- Southern Research