Synthesis of Antidotes for Organophosphorus Acetylcholinesterase Inhibitors
Abstract
This report describes the preparation of 73 new compounds prepared for evaluation as antidotes and/or prophylactic agents against the toxicity of organophosphorus acetylcholinesterase inhibitors. The compounds prepared included: heteroaromatic bis-cations (11 examples); heteroaromatic mono-cations (13 examples); phenoxymethyl heteroaromatic carbamates (12 examples); imidazopyridinium salts (32 examples); and miscellaneous compounds (5 examples). The preparative methods are described. For any compound in vitro activity as inhibitors of acetycholinesterase is given. Some compounds have also been evaluated for in vivo prophylactic and antidotal activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 30, 1991
- Accession Number
- ADB159050
Entities
People
- Richard J. Sundberg
Organizations
- University of Virginia