Drug Development against Viral Diseases

Abstract

Ninety-three drugs were tested against LCMV in the adult mouse model. Fourteen drugs gave VR scores greater than 1.2 which places these drugs in the top 90th percentile of all drugs tested in the LCMV model. The identity of the ribavirin resistant virus has been established by mouse neutralization test using acetone-ether extracted CCHF virus mouse polyclonal antibody. There were no breakthrough mice in the neutralization test. Ribavirin-resistant virus was re-isolated from liver tissue of infected mice.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1990
Accession Number
ADB161297

Entities

People

  • Gregory M. Tignor

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Infective Agents
  • Biomedical Research
  • Blood Coagulation Factors
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Ebola Virus
  • Health Care
  • Health Services
  • Infection
  • Medical Personnel
  • Poxviridae Infections
  • Rodents
  • Vaccines
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Gender and Food Studies
  • Virology (or Medical Virology).