Conduct Studies to Synthesize Antiviral Compounds

Abstract

Ribavirin a broad spectrum antiviral compound shows promise in vitro and in vivo against many viral diseases. The specific aim of this project was to synthesize a polymeric drug conjugate of ribavirin to provide time-release doses with enhanced endocytosis. A practical and standard approach was planned to couple ribavirin with carboxy-dextran (MW 46,000) by protecting 2', 3'-hydroxyl groups of ribavirin and then coupling ribavirin with polymer via an ester linkage to the 5'-hydroxyl group. This report describes successful synthesis and characterization of 2' 3'-isopropylidine ribavirin and carboxy-dextran. Conjugation of ribavirin to polymer may provide enhanced solubility and sustained release of drug. Further, a recommendation is also made in this report to achieve successful synthesis of conjugates.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 18, 1992
Accession Number
ADB162349

Entities

People

  • Devinder Gill

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Animals
  • Antiviral Agents
  • Biomedical Research
  • Cells
  • Chemistry
  • Column Chromatography
  • Contracts
  • Diseases And Disorders
  • Freeze Drying
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Methanols
  • Mixtures
  • Standards
  • Virus Diseases

Fields of Study

  • Chemistry

Readers

  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biochemistry
  • Organizational Process Management (OPM).