Research in Drug Development against Viral Diseases of Military Importance (Large-Scale Antiviral Drug Screening). Volume 2. Appendices
Abstract
The purpose of this program was to evaluate the efficacy of candidate antiviral compounds against a of viruses of military importance. This program involved (a) prescreen testing of natural products for antiviral efficacy in vitro, (b) primary testing of synthetic compounds and active natural products in vitro against an expanded of v of military importance, (c) confirmatory testing of all active lead compounds from the prescreen and primary screen, (d) secondary in vitro and in vivo studies of selected active compounds with best broad spectrum antiviral activity. The target viruses for in vitro testing were Vaccinia Virus (VV), Yellow Fever Virus (YF), Japanese Encephalitis Virus (JE), Venezuelan Equine Encephalomyelitis Virus (VE), Punta Toro Virus (PT), Sandfly Fever Virus (SF) and Human Immunodeficiency Virus (HIV). The secondary in vitro and in vov testing was carried out with three major classes of viruses (a) Filoviruses, (b) Arenaviruses and (c) Bunyaviruses. Approximately 5500 (2762 prescreen compounds and 2713 primary screen compounds were received for in and over 34,000 assays were performed on this contract. Compounds were identified in nearly all virus systems that have confirmed antiviral activity equal or exceeding that of the various positive control compounds (Ribavirin, Selenazofurin, Ara-A, ddC and AZT). Many of these compounds represent potent and selective new antiviral agents. Antiviral Drugs, In Vitro, HIV. Exotic RNA Viruses, In Vivo, DNA Viruses, RA 1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1991
- Accession Number
- ADB166043
Entities
People
- A. Brazier
- E. Stephen
- G. Arnett
- J. Kirsi
- W. Shannon
Organizations
- Southern Research