Feasibility of a Subunit Vaccine for Hepatitis A Virus: Studies on the Pathogenesis of Hepatitis A and Feasibility Studies on a Hepatitis A Vaccine.

Abstract

The overall goals of this contract are to explore the feasibility of the development of a subunit vaccine for hepatitis A virus (HAV). We have produced HAV structural proteins by recombinant DNA technology and characterized them as antigens for the induction of protective immunity. We have analyzed the replication strategies of HAV which contribute to its distinguishing growth properties and we have identified the HAV protein 3C as a viral protease. We have evaluated the human immune response to HAV infection. Hepatitis A virus, Subunit vaccine, RA I, Typhus, Virus, Vaccines, Biotechnology.

Document Details

Document Type
Technical Report
Publication Date
May 01, 1992
Accession Number
ADB171993

Entities

People

  • Elvera Ehrenfeld

Organizations

  • University of Utah

Tags

DTIC Thesaurus Topics

  • Bacterial Infections And Mycoses
  • Biological Sciences
  • Biotechnology
  • Contracts
  • Deoxyribonucleic Acids
  • Diseases And Disorders
  • Feasibility Studies
  • Hepatitis
  • Immunity
  • Infection
  • Pathogenesis
  • Recombinant Dna
  • Vaccines
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology