Drug Evaluation in the Plasmodium Falciparum - Aotus Model
Abstract
The Panamanian Aotus - Plasmodium falciparum model was used to evaluate potential antimalarial rugs; additionally, ah Aotus-adapted P. vivax strain was tested for its susceptibility to chloroquine. A water-soluble form of WR 268668, a bisoquinoline was ineffective against Vietnam Smith/RE infections. Two trioxanes (WR 279137 and WR 279138) and a tetroxane (WR 148999) cured infections at doses equivalent to arteether (WR 255131) used as a positive drug control for these experiments. Infections of the Singleton strain of P. vivax were cured by doses of chloroquine that routinely cure such infections, showing that these parasites did not demonstrate a resistance to chloroquine. In a third trial to reverse chloroquine resistance in vivo (Smith/RE infections), a loading dose of chloroquine was followed eight hours later with a dose of promethazine. Primary treatments only suppressed parasitemias while re-treatments at 2x the respective primary dose cleared parasitemias. Post treatment blood film examination to ascertain infection cure is in progress. RA J, Malaria, P. Falciparum, Aotus monkey, Antimalarial, Drug evaluation, Lab animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 23, 1993
- Accession Number
- ADB173254
Entities
People
- Richard N. Rossan