Unique Enzyme Targets for Gonococcal Antimetabolites. Phase 1
Abstract
A rationale exists in support of the possibility that the lactate dehydrogenase isoenzymes of Neisseria gonorrhoeae might be essential enzymes for maintaining the host-pathogen relationship. Specific aims for Phase I were to employ lactate dehydrogenase mutants and selective inhibitors of the membrane-bound lactate dehydrogenase (iLDH) and soluble lactate dehydrogenase (NLDH) in genetic and physiological experiments to gain an understanding of the redox relationships and overall biochemical roles of iLDH and nLDH. Success in this approach would provide the basis for a Phase II project for determining the gene sequences and for the design of precise inhibitors acting at the enzyme, or perhaps the gene level. These inhibitors can then be deployed in model systems of pathogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1992
- Accession Number
- ADB176142
Entities
People
- Randy S. Fischer