Neutralizing Monoclonal Antibodies against Biological Toxins. Phase 1

Abstract

This SBIR project was broken down into two separate phases. The first phase served to demonstrate that a human immune response could be generated to the A-chain of ricin. The second phase centered on the immortilization of this immune response. A human immune response, though weak, to ricin A-chain was observed using IVI protocols. Different patient's spleenocytes were found to respond differently to in vitro immunization protocols with ricin A-chain as an antigen. To further improve the human immune response to rAc, different adjuvant-like compounds should be used. (e.g., rAc coupled to a highly immunogenic macromolecule). With the protocols used to date, the predominant immune response generated was of the IgM type. Essentially, no IgG MAbs were detected. RA I, SBIR, Antibody, Toxins, BL2, BD.

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Document Details

Document Type
Technical Report
Publication Date
Aug 14, 1993
Accession Number
ADB176298

Entities

People

  • Mark C. Glassy

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Biological Toxins
  • Biomedical Research
  • Cells
  • Contracts
  • Health
  • Immunization
  • Laboratory Animals
  • Lymphocytes
  • Macromolecules
  • Materials
  • Molecules
  • Polymers
  • Proteins
  • Public Health
  • T Lymphocytes

Fields of Study

  • Biology

Readers

  • Immunology
  • Nuclear Civil Defense.
  • Theoretical Analysis.