Chemotherapy of Leishmania with Oligodeoxynucleotide Probes

Abstract

The research covered by this contract investigates the utility of oligodeoxynucleotides (hereinafter called oligonucleotides or ODNs) as antileishmanial agents. The sequence of these ODNs is antisense to the spliced leader sequence of certain mRNA in the Leishmania sp. The scope of the work comprises the exploration of structural modifications that should increase the potency of these ODNs as antiparasitic agents. These modifications include those that improve the hybrid strength (receptor affinity), stability to degradation, and cell penetration of the oligonucleotides. Chemotherapy, Leishmania, DNA probes, RNA Probes, Biotechnology, ID, SBIR 88.II.

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Document Details

Document Type
Technical Report
Publication Date
Apr 12, 1993
Accession Number
ADB187024

Entities

People

  • Rich B. Meyer

Tags

DTIC Thesaurus Topics

  • Acids
  • Acquisition
  • Acridines
  • Antiparasitic Agents
  • Biomedical Research
  • Cells
  • Chemotherapy
  • Cholesterol
  • Contracts
  • Corporations
  • Degradation
  • Deoxyribonucleic Acids
  • Leishmania
  • Microprobes
  • Nucleic Acids
  • Probes
  • Sequences

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular Biology and Genetics
  • Parasitology and Pharmacology of Malaria.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech