Microencapsulation of Drugs in the Microgravity Environment of the United States Space Shuttle

Abstract

The objective of the MIS-B experiment is to demonstrate the feasibility of producing pharmaceutical microspheres in a microgravity environment. To meet this objective, a drug, ampicillin anhydrate, will be microencapsulated in space. By choosing this drug, a direct comparison between earth-and space-produced microspheres can be performed. Ampicillin anhydrate microspheres have been made on earth. In addition, we have shown from the results of MIS-A that the manufacturing microspheres in the microgravity environment of space can improve the quality of the microspheres. Knowledge gained by this research will indicate whether pharmaceuticals which previously could not be microencapsulated on earth due to solvent incompatibilities or diffusional dilution could be easily microencapsulated in space. Microencapsulation would enable these drugs to be administered in a controlled-release fashion which could increase their therapeutic value

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Document Details

Document Type
Technical Report
Publication Date
Oct 03, 1994
Accession Number
ADB192333

Entities

People

  • Richard J. Holl
  • Thomas R. Tice

Organizations

  • Southern Research

Tags

Communities of Interest

  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Air Force
  • Biomedical Research
  • Brushless Dc Motors
  • Chlorides
  • Control Panels
  • Detectors
  • Electromagnetic Interference
  • Electronic Components
  • Fabrication
  • Manufacturing
  • Microcapsules
  • Power Converters
  • Power Supplies
  • Recording Systems
  • Solenoid Valves
  • Video Recording
  • Wound Infections

Readers

  • Aerospace Engineering.
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Systems Analysis and Design

Technology Areas

  • Space
  • Space - Satellites