Drug Evaluation in the Plasmodium falciparum - Aotus Model
Abstract
A pyrroloquinazoline was toxic to Aotus. Blood induced infections of the AMRU-1 P. vivax strain were not cured with primaquine plus chloroquine. A primaquine analog plus chloroquine cured infections with CQR vivax parasites, indicating in-Vivo reversal. The FVO P. falciparum strain was reestablished in Panamanian Aotus to induce immunity acquire by repeated trophozoite challenge. Patent infections were induced in Aotus by Santa Lucia P. falciparum strain trophozoites and sporozoites, a potential model to evaluate DNA vaccines. A DNA plasma vaccine encoded for the p. yoelli CSP gene elicited significant antibodies by intradermal needle injection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 24, 1995
- Accession Number
- ADB198405
Entities
People
- Nicanor Obaldia
- Richard N. Rossan