Synthesis of Antidotes and Prophylactics for Organophosphorus Acetylcholinesterase Inhibitors
Abstract
Work has been completed on 4-substituted and 6-substituted N,N-Dimethylcarbaaoyloxy derivatives in the imidazo 1,2-Apyridinium series (six new compounds). Previously four 8-substituted compounds had been prepared. Work has been begun on the 7-substituted series. In each series the goal is to prepare the parent compound and three 2-substituted analogs containing methyl, isopropyl and phenyl substituents. In vitro biological assays have been performed on all available derivatives (eleven compounds). The 4- and 8-substituted analogs are more active than the 6-substituted compounds.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1995
- Accession Number
- ADB200784
Entities
People
- Richard J. Sundberg
Organizations
- University of Virginia