Production of Polyclonal Antibodies in Rabbits

Abstract

The project was directed to the Medical Chemical Defense Research Program. Under the broad mission of providing medical countermeasures to chemical warfare agents, the work was relevant to develop the use of exogenous cholinesterase enzymes as a pretreatment to protect against organophosphorous chemical agents. The threat of deadly exposure to chemical agents is still significant for American military personnel and the American public. The recent use of sarin by Japanese extremists in subway sta- tions in Japan is witness to that. Amongst the most lethal chemical agents are organophosphorous (OP) compounds such as soman, sarin, and tabun. Poisoning from these agents can lead to rapid and severe dysfunction and even death from respiratory failure within five minutes (Gilman, et al., 1990).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1995
Accession Number
ADB205250

Entities

People

  • Elis S. Nuwayser

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Calcium Compounds
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Chlorides
  • Congestion
  • Hyperplasia
  • Immune Serums
  • Immune System
  • Lymphatic System
  • Medical Personnel
  • Microcapsules
  • Peripheral Nervous System
  • Sodium Compounds

Readers

  • Immunology
  • Neurotoxicology
  • Political Violence and Terrorism Studies.