Drug Evaluation in the Plasmodium Falciparum-Aotus Model
Abstract
Its metabolite (desbutylhalofantrine) was less effective than halofantrine in curing Vietnam Oak Knoll P, falciparum infections, MSP-1, a DNA erythrocytic vaccine did not prevent virulent infections after Oak Knoll challenge. Sterile immunity in Aotus has been achieved by repeated Oak Knoll challenges. A fourth immunization with a DNA pre-erythrocytic vaccine has produced high antibody levels. To date, sporozoites of the 3D7 clone of P, falciparum have not produced patent infections. Vaccination with Interleukin-12 did not yield gamma interferon in Aotus, A fourth (i.d.) vaccination with DNA Py CSP vaccine generated highly significant antibody titers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1996
- Accession Number
- ADB210896
Entities
People
- Nicanor Obaldia Iii.
- Richard N. Rossan