Enterotoxin Vaccine Delivery System With Bioadherence. Phase 1.

Abstract

The primary of this Phase I program was to provide a stable peroral controlled delivery system for a vaccine which was designed to release its contents in the intestinal tract with or without an immunoadjuvant. A single administration of the vaccine must release at a rate sufficient for inoculation of the host immune system for up to six months. To insure sustained release in an environment as dynamic as the intestinal mucosa, adherence to the host tissue for several days is essential. Adhesion of this magnitude will require a delivery system configured with a bioadhesive polymer.

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Document Details

Document Type
Technical Report
Publication Date
Dec 05, 1995
Accession Number
ADB212163

Entities

People

  • Ronald P. Dues

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Bacteria
  • Biodegradable Plastics
  • Biomedical And Dental Materials
  • Blood
  • Bodily Secretions
  • Carboxylic Acids
  • Chemistry
  • Environment
  • Gastrointestinal Tract
  • Immune System
  • Medical Personnel
  • Microcapsules
  • Physical Properties
  • Polymeric Films
  • Polymers
  • Small Intestine

Readers

  • Immunology
  • Software Engineering

Technology Areas

  • Biotechnology