A Role for the NFkB/Rel Transcription Factors in Human Breast Cancer
Abstract
Human breast cancer is characterized by the inappropriate expression of growth factors, kinases and possibly certain transcription factors. Our project focuses on the potential role of a family of transcription factors known as NF-kB/Rel in human breast cancer. Additionally, the project will analyze a role for VNTR elements in the hereditary susceptibility of women to breast cancer and on a role for estrogen in modulating cell growth of human breast cancers. It has been reported previously that certain genes known to be regulated by NF-kB/Rel proteins are inappropriately activated in human breast cancer. We have explored mechanisms that may be involved in the activation of NF-kB/Rel proteins in human breast cancer. Our data ruled out the general mechanism of induced nuclear translocation, but new data indicates that NF-kB can be activated through a novel mechanism involving targeting of the transcriptional activation function of the NF-kB p65 subunit. We are presently exploring the role and requirement of NF-kB in human breast cancer and whether this transcription factor is involved in responses to oncogenes, to estrogen and whether it controls gene expression induced by VNTR elements.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1996
- Accession Number
- ADB216052
Entities
People
- Albert S Baldwin
Organizations
- University of North Carolina at Chapel Hill