Oral Vaccination Against Anthrax Using a Transgenic Plant Expressing Protective Antigen.
Abstract
The goal of this proposal is to develop transgenic plants for the production of oral food-based delivery of new recombinant vaccines against the plague and anthrax. The major goal of the Phase 1 contract was to generate transgenic plant material expressing three different antigens: the Bacillus anthracis protective antigen (PA), the Yersinia pestis V antigen modified to contain a His6 epitope to facilitate affinity purification (His-Tag V), and the Y pestis F1 antigen, with potential for anthrax and bubonic plague vaccines, respectively. We will briefly introduce the disease and the rationale for selection of targeted antigens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADB218568
Entities
People
- Karen K. Oishi