Extrudable Gel-Forming Bioabsorbable Hemostatic Tissue Adhesives for Traumatic and Burn Wounds
Abstract
Two of the three segments of the planned studies, adhesive skin wound augmentation (ASWA) and burn wound healing (BWH) are underway. Plans for the third segment, hemostasis, have been finalized. The studies on ASWA are practically complete and they include: (1) polymer synthesis and characterization of primary gel-formers; (2) preparation and evaluation of candidate formulations; and (3) conducting the animal studies and completing data analysis. Studies on BWH are in progress and they include (1) preparation and evaluation of candidate formulations, and (2) initiation of the animal studies. Results of the study on the effect of gel-forming formulations on skin wounds indicate that (1) using gel-formulations without antibiotics can lead to improved wound healing and increase in wound strength regain with partial reliance on mechanical stapling, and (2) high concentrations of the antibiotic vancomycin compromises the wound healing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1996
- Accession Number
- ADB218632
Entities
People
- Shalaby W. Shalaby