Human Breast Cancer Cell Proliferation and Modulation by Melatonin and Environmental Magnetic Fields.
Abstract
The overall purpose of this study is to investigate the role that environmental-level magnetic fields may play as an exogenous factor in the etiology of human breast cancer. There are several important observations that have been made during the research conducted in this reporting period. We have further characterized the EMF blocking effect on the oncostatic action of melatonin and tamoxifen on human breast cancer cell growth in vitro. Field dose studies suggest that this blocking effect is observed at field strengths of up to 1Gauss (1000mG, 100uTesla) with a lower threshold between 6 - 12mG. Studies investigating the critical duration of exposure suggest that at least two days of continuous field exposure is required; this corresponds to one cell-cycle period. In biologically-based studies it was shown that melatonin concentration in the media itself is not influenced by a 2 vs 12mG magnetic field. The original melatonin findings presented in our proposal recently have been independently replicated at the EPA.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADB218884
Entities
People
- Robert P. Liburdy
Organizations
- University of California, Berkeley