Tumor Suppressor Genes in Early Breast Cancer and Its Progression.
Abstract
An increasing percentage of breast cancer is being detected at a pre-invasive stage: ductal carcinoma in situ (DCIS). DCIS is a form of breast cancer in which malignant cells have not penetrated the basement membrane. The histopathological diagnosis encompasses a heterogeneous group of subtypes, including comedo, cribriform, solid, papillary and micropapillary, some of which may differ in biological behavior. The potential for associated micro invasion and likelihood of recurrence after breast conservation therapy are higher with the comedo subtype. As with invasive breast cancer, DCIS can also be stratified by nuclear grade: high, intermediate, and low. Our studies have concentrated on the genetic changes which occur in DCIS and the transition from DCIS to invasive breast cancer. A better understanding of the oncogenesis of breast cancer at the molecular level, and the correlation of this information with clinical data, may aid in treatment choices.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADB220521
Entities
People
- Diane M. Radford
Organizations
- University of Washington