Mechanisms of Integrin-Mediated Growth Control in Normal, Transformed, and Neoplastic Breast Cells
Abstract
The interaction between a normal cell and its substratum, a phenomenon known as anchorage dependence, is an important determinant of the GI/S transition. The cell surface receptors that mediate cell-substrate adhesion are known as integrins. Integrins are transmembrane glycoproteins. It is possible that extracellular matrix proteins regulate normal cell growth by transmitting signals to the interior via specific integrin receptors. In transformed cells such signaling pathways might be absent or dysfunctional thereby conferring unresponsiveness to normal growth constraints. The present studies are focused to understand how integrin receptors, in particular alpha 5 Beta 1, participate in the regulation of cell division in normal breast cells and to determine how breast cancer cells escape these regulatory pathways. Our initial results indicate that soluble GRGDS peptides can alter cell cycle kinase activity in both normal breast cells and in some carcinoma cell lines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADB222349
Entities
People
- Elizabeth Wayner
Organizations
- Center for Global Infectious Disease Research