Estrogen Receptor Mutants/Variants in Human Breast Cancer.

Abstract

We have identified in a range of human breast cancer biopsy samples, several known and unknown estrogen receptor (ER) variant mRNAs as well as some ER mRNAs containing inserted nucleotide sequences. The variant ER mRNAs are likely generated by alternative splicing mechanisms, while the inserted ER mRNAs are likely to be generated from a mutated ER allele in the tumor cells. All types of variant ER mRNAs so far identified, could be detected in normal human mammary tissue. The expression of some of these variant ER mRNAs was significantly higher in breast tumors than in normal breast tissue. Moreover, the pattern of ER variant mRNA expression changes in breast tumors and breast cancer cells with characteristics of poor prognosis and lack of sensitivity to endocrine therapies.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1996
Accession Number
ADB222447

Entities

People

  • Leigh C. Murphy

Organizations

  • University of Manitoba

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Gene Expression
  • Genetics
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.