Lewis Y Antigen as a Target for Breast Cancer Therapy
Abstract
The Lewis Y antigen is a breast cancer associated carbohydrate antigen The basis of the current program is to utilize structural information for Lewis Y-antibody interactions to develop novel immunotherapeutics for Breast Cancer treatment. To develop such immunotherapeutics, we have constructed smaller forms of anti-Lewis Y antibodies, established that bispecific antibodies that include anti-Lewis Y antibodies can enhance the targeting of breast tumors, and have developed peptides that mimic breast associated carbohydrate antigens capable of inducing immune responses to breast tumors, mediating their killing in vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1996
- Accession Number
- ADB222453
Entities
People
- Thomas Kieber-emmons
Organizations
- University of Pennsylvania