Biochemistry and Chemotherapy of Leishmaniasis and Malaria

Abstract

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis and malaria. The objective of this research was to: (1) Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., (2) To identify and characterize unique DNA synthetic enzymes for the purpose of chemotherapeutic exploitation and (3) To test potential compounds sent by WRAIR and others for anti- parasitic activity.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1995
Accession Number
ADB222551

Entities

People

  • Linda Nolan

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacterial Infections
  • Biological Products
  • Cells
  • Chemistry
  • Chemotherapy
  • Drug Abuse
  • Fungi
  • Glycosides
  • Infection
  • Materials
  • Microbiology
  • Plant Extracts
  • Public Health

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Parasitology and Pharmacology of Malaria.