Studies on Platelet-Derived Growth Factor Beta-Receptor and Hepatocyte Growth Factor Receptor c-met in Paracrine Interactions in Human Breast Cancer

Abstract

The overall aim of our project is to identify paracrine and autocrine mechanisms that regulate stromal-tumor cell interactions in breast cancer. We have shown that platelet-derived growth factor (PDGF) Beta-receptors, which are high affinity receptors for PDGF-BB, are upregulated in vascular endothelial cells and smooth muscle actin-expressing cells (most likely myofibroblasts) at the peri-epithelial stroma in DCIS of human breast tumors. Our results suggest that breast carcinoma cells, which secrete PDGF-BB, stimulate vascularization by endothelial cells and recruitment of myofibroblasts in the peri-epithelial stromal regions of early stage breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1996
Accession Number
ADB224557

Entities

People

  • Bruce E. Elliott

Organizations

  • Queen's University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Breast Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Health Services
  • Medical Personnel
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).