Role of Raf-1 Signaling in Breast Cancer - Progression to Estrogen Independent Growth

Abstract

In order to study the role of Raf-1 kinase signaling in the progression of breast cancer from estrogen-dependent to estrogen-independent growth, we had previously established several clones of MCF-7 cells stably expressing a truncated, constitutively active Raf and examined these clones for their ability to grow in the absence of estrogen.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1996
Accession Number
ADB224562

Entities

People

  • Dorraya El-ashry

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Growth Factors
  • Materials
  • Modulators
  • Molecular Dynamics
  • Neoplasms
  • Programmed Cell Death
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics