Episome-Based Gene Therapy Strategy for Treatment of Human Breast Cancer

Abstract

E HAVE FOCUSED OUR EFFORTS ON INVESTIGATING THE EFFECTIVENESS OF ANTISENSE TO TYPE I insulin-like growth factor receptor (IGF-IR) in reducing tumorigenicity in highly metastatic human breast cancer cells, MDA-MB-435S and murine breast cancer cells, EMT6 in vitro and in vivo. A new construct for antisense IGF-IR has been prepared and transfections were carried out in these cell lines. Clones expressing high levels of antisense IGF-IR and reduced IGF-IR RNA were selected for analysis.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1997
Accession Number
ADB224571

Entities

People

  • Judith Ilan

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cultured Cells
  • Gene Therapy
  • Genetics
  • Health Services
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Tumor Cell Line

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech