Iron Deprivations Treatment of Breast Cancer: Pre-Clinical Studies

Abstract

Progress has been made in the study of iron deprivation as a potential treatment modality for breast cancer. Enhanced macrophage activation with an augmented acute phase response has been implicated as a source of potential treatment related toxicity. Deferoxamine appears to interact successfully with Doxorubicin in vitro in inhibiting the growth of some breast cancer cell lines. New, direct evidence for iron-deprivation inducing apoptosis arose in a collaborative study and has been submitted for publication. Sufficient monoclonal antibody reagents are now on hand to begin in vivo anti-tumor experiments with the MDA-MB-231 breast cancer cell line.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1997
Accession Number
ADB225250

Entities

People

  • John D. Kemp

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Deprivation
  • Electron Microscopy
  • Health Services
  • Macrophages
  • Materials
  • Neoplasms
  • Programmed Cell Death
  • Toxicity

Readers

  • Oncology (Cancer Research).