Biological Markers of Environmental Carcinogens in Breast Cancer
Abstract
This ongoing case-control study is being conducted at the Columbia Presbyterian Medical Center (CPMC) and is investigating whether exposures to polycyclic aromatic hydrocarbons (PAH) and heterocyclic amines (HA), widespread environmental and dietary contaminants are associated with risk of breast cancer. The study is designed to enroll 100 cases and 100 benign breast disease (BBD) controls from whom blood, biopsy tissue and questionnaire data are being collected and 100 healthy controls from whom blood and questionnaire data are being collected. The study is utilizing biomarkers (PAH-, HA-, and smoking related-DNA adducts) as measures of exposure and p53 mutations as a biomarker of pre-clinical effects. Years one and two have focused on patient recruitment, interviewing and laboratory analyses. Progress in patient recruitment has been excellent and is running ahead of schedule with 311 patients currently enrolled. Samples have been analyzed for carcinogen-DNA adduct levels and p53 expression and descriptive statistical analyses of the data are presented. Additionally, samples have been used for several pilot studies and the descriptive analyses for these biomarkers are presented as well
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1996
- Accession Number
- ADB225344
Entities
People
- Frederica Perera
Organizations
- Columbia University