Identification and Characterization of Molecular Abnormalities of 11p Genes in Human Breast Cancer

Abstract

This project is based on the hypothesis that at least one tumor suppressor gene on chromosomal band 11p15 is involved in breast cancer progression. This hypothesis is based on the fact that loss of heterozygosity (LOH) of 11pl5 occurs in at least half of breast cancers that metastasize, and that a normal chromosome 11 suppresses tumorigenicity of MCF-7 breast cancer cells. The purpose of these studies is to localize and identify an 11p15 breast cancer gene.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1996
Accession Number
ADB225776

Entities

People

  • Andrew P. Feinberg

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Chemistry
  • Chromosomes
  • Deoxyribonucleic Acids
  • Epithelial Cells
  • Gene Expression
  • Genetics
  • Growth Factors
  • Health Services
  • Materials
  • Molecular Dynamics
  • Neoplasms
  • Polymerase Chain Reaction
  • Stromal Cells

Readers

  • Molecular Biology and Genetics