Integration of Text, Image, and Chemistry Databases on GUI Clients Designed for Drug Discovery and Development
Abstract
The purpose of this effort was to create a prototype Chemical Information System that integrates chemical, biological and inventory databases into a Graphical User Interface (GUI) for drug discovery. TR1Mtools, a 4th generation C like language from Trifox Inc, were used to create the GUI because of their low cost, high performance, platform independence and library functions for database management across networks. Thin and thick client GUIs were written for Windows NT/95/3.1 and a Java Client written for all major platforms including MacOS. These clients manage simultaneous connections to a Daylight chemical database on a Sun Solaris, an Rdb database on a Vaxstation and an Image database on a jukebox. Data from each server are merged within the GUI window or displayed by helper applications. Both 2D and 3D chemical structures, Thor Datatrees, and Merlin similarity searches from the Daylight CGI are displayed in a Netscape browser and a RasMol window. Images of Chemical Data Sheets stored as tiff files and reference monographs stored as PDF files were displayed in graphical viewers. The need to code printer specific reports was eliminated by writing text and images into dynamic HTML that is printed from the client's browser. These features were used to format custom screens to enable biologists, chemists and supporting staff to manage high throughput analyses typical of the pharmaceutical industry.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1997
- Accession Number
- ADB225895
Entities
People
- Patrick Mcgreavy