The Role of Osteopontin in the Malignancy of Human Breast Carcinoma
Abstract
The objective of this research is to establish whether the secreted phosphoprotein osteopontin (OPN) plays a biological role in the progression of breast carcinoma cells, and to determine the nature of this role, by asking if cell properties and genes associated with malignancy are regulated by OPN. This work makes use of a cell culture model system (the 21T series), which includes three established mammary epithelial cell lines derived from the same patient. 21PT cells are immortal but nontumorigenic in the nude mouse; 2lNT are weakly tumorigenic, but non-metastatic; and 2lMT-l are tumorigenic, weakly metastatic.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADB228777
Entities
People
- Alan B. Tuck
- Frances O'malley