Injectable Absorbable Ocular Inserts for Controlled Drug Delivery
Abstract
Phase I of this program was intended to determine feasibility of using novel absorbable liquid gel-formers (GF) for injectable intravitreal and/or subconjunctival formulations of key drugs for four different indications. And Phase I results do demonstrate the feasibility of preparing injectable controlled release formulations of pilocarpine PC as a model diagnostic drug used in treating glaucoma the antiviral ganciclovir GC for cytomegalovirus (CMV) retinitis, the immunosuppressant cyclosporin A CP for chronic uveitis, and naproxen NP as a non-steroidal anti-inflammatory drug. Results of in vitro and in vivo release studies, eye examination, and histological evaluation of pertinent tissues are discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADB229497
Entities
People
- Shalaby W. Shalaby