Novel Approaches to Preventing Urinary Tract Infection in Women

Abstract

Urinary tract infections (UTIs), generally caused by Escherichia coli or Staphylococcus saprophyticus, are extremely common among young women and 25% of these patients develop frequent recurrent infections. Although UTIs can be treated, we currently lack effective means to prevent UTI in women. A necessary prerequisite to UTI is adherence of uropathogens to the vaginal and bladder epithelium. This report describes the first year of progress in a project whose overall goal is to define uropathogen-binding GSLs in the vaginal and bladder epithelium as a prerequisite to the rational design of new agents that will prevent colonization and infection in women.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADB232738

Entities

People

  • Ann E Stapleton

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Biochemistry
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Epithelial Cells
  • Eukaryotes
  • Health Services
  • Infection
  • Liquid Chromatography
  • Mass Spectrometry
  • Medical Personnel
  • Organic Chemistry
  • Spectrometry

Fields of Study

  • Medicine

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