Screening for Ataxia-Telangiectasia Mutations in a Population-Based Sample of Women With Early-Onset Breast Cancer
Abstract
We are assessing whether a mutated allele of the Ataxia-telangiectasia gene, ATM, is a genetic risk factor for breast cancer, by screening for ATM mutations in patients with early- onset breast cancer. These patients were derived from a large population-based, case-control study of primary breast cancer in Western Washington. We are screening genomic DNAs by SSCP (single strand conformation polymorphism) analysis of the 62 coding exons amplified by multiplex PCR. In 87 early-onset breast cancer cases, we have found no truncation or deletion mutations in the ATM gene. We have detected five cases of possible missense mutations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADB232741
Entities
People
- Sharon Teraoka