Tumor Suppressor Genes in Early Breast Cancer and its Progression

Abstract

An increasing percentage of breast cancer is being detected at a pre-invasive stage: ductal carcinoma in situ (DCIS). DCIS is a form of breast cancer in which malignant cells have not penetrated the basement membrane. The histopathological diagnosis encompasses a heterogeneous group of subtypes, including comedo, cribriform, solid, papillary and micropapillary, some of which may differ in biological behavior. Our studies have concentrated on the genetic changes which occur in DCIS and the transition from DCIS to invasive breast cancer. A better understanding of the oncogenesis of breast cancer at the molecular level, and the correlation of this information with clinical data, may aid in treatment choices.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1997
Accession Number
ADB232934

Entities

People

  • Helen Donis-keller

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cells
  • Chromosomes
  • Genes
  • Genetics
  • Health Services
  • Intervals
  • Materials
  • Medical Personnel
  • Neoplasms
  • Polymerase Chain Reaction
  • Radiation
  • Suppressors

Fields of Study

  • Chemistry

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology