Megakaryocytopoiesis in Stem Cell Transplantation

Abstract

The overall objective of this research proposal is to investigate several laboratory protocols to improve megakaryocyte production for future clinical use of an autologous megakaryocyte-rich product. Conditioned medium from bone marrow stromal cultures enhances the thrombopoietin stimulated megakaryocyte production by at least 3-fold by a still unknown mechanism. We were able to rule out any role of stromal concentrations of thrombopoietin, interleukins 3 and 6, stem cell factor and heparan sulfates on this enhancing effect.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADB233503

Entities

People

  • Isaac Cohen

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Bone Marrow
  • Bone Marrow Cells
  • Breast Cancer
  • Cells
  • Chemistry
  • Culture Media
  • Culture Techniques
  • Diseases And Disorders
  • Granulocytes
  • Growth Factors
  • Health Services
  • Proteins
  • Stem Cells
  • Transplants

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation