Development of Intraductal Techniques for Breast Cancer Prevention, Diagnosis, and Treatment
Abstract
The purpose of this project was to develop a reliable, non invasive technique to gain access to the lining of the milk ducts. In a previous IDEA grant (DAMD17-94-J-4281) we demonstrated the feasibility of an intraductal approach to breast disease, the ability to obtain ductal cells through washings, and the general anatomy of the nipple duct orifices and ductal systems. After studying the microanatomy of the ductal orifices, we proceeded to develop a technique for identifying the breast duct orifices. This involves dekeratinizing the nipple and applying a fluorescing keratin antibody to the ductal epithelium. Once this approach has been demonstrated we will proceed to utilize it to further confirm the ductal orifice anatomy. The second accomplishment has been to demonstrate that we can reliably retrieve cells from a duct cannulated with a double lumen catheter.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADB233743
Entities
People
- Susan Love
Organizations
- University of California, Los Angeles