Vascular Functional Imaging and Physiological Environment of Hyperplasia, Non-Metastatic and Metastatic Breast Cancer

Abstract

Our research proposal consists of the following three closely related aims directed towards understanding the role of vascular, physiological and metabolic properties in the metastatic dissemination of breast cancer. Aim 1: To investigate the relationship between metastatic phenotype and the development of vascularization and evaluate the functionality of the developing vascularization in terms of vascular volume, vascular permeability and relative perfusion. Aim 2: To investigate the effect of increasing (a) tumor vascularization and (b) tumor vascularization and permeability on the formation of metastases. Aim 3: To determine the relationship between metastatic phenotype and intra- and extracellular pH and lactate production.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADB233883

Entities

People

  • Zaver M. Bhujwalla

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Confidence Limits
  • High Resolution
  • Histological Techniques
  • Materials
  • Metabolism
  • Neoplasms
  • Proteins
  • Three Dimensional
  • Veins

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Oncology (Cancer Research).