Biological Markers of Environmental Carcinogens in Breast Cancer
Abstract
This ongoing case-control study is being conducted at the Columbia Presbyterian Medical Center (CPMC) and is investigating whether exposures to the environmental and dietary contaminants polycyclic aromatic hydrocarbons (PAR) and heterocyclic amines (HA) are associated with risk of breast cancer. The study is designed to enroll 100 cases and 100 benign breast disease (BBD) controls from whom blood, biopsy tissue and questionnaire data are being collected, as well as 100 healthy controls from whom blood and questionnaire data are being collected. The study is utilizing biomarkers (PAN-, HA-, and smoking related-DNA adducts) as measures of exposure and a biomarker of pre-clinical effects (p53 muations). During year three, patient recruitment continued and an increased focus was placed on the laboratory aspects of the study. Progress in patient recruitment has been excellent and is running ahead of schedule with 384 patients currently enrolled. Thus far, a total of 2,400 analyses have been performed on blood samples and 351 analyses have been performed on tissue samples . Descriptive statistical analyses of the data have been carried out. Additionally, samples have been used for several pilot studies and the descriptive analyses for these biomarkers are presented as well.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADB234439
Entities
People
- Frederica P. Perera
Organizations
- Columbia University